The effects of acute chloroquine poisoning with special reference to the heart
Identifieur interne : 003C04 ( Main/Exploration ); précédent : 003C03; suivant : 003C05The effects of acute chloroquine poisoning with special reference to the heart
Auteurs : T. A. Don Michael [Iran] ; S. Aiwazzadeh [Iran]Source :
- American Heart Journal [ 0002-8703 ] ; 1970.
English descriptors
- Teeft :
- Acute chloroquine, Acute poisoning, Adrenaline, Angina pectoris, Animal experiments, Aortic, Aortic pressure, Atria1 flutter, Atrial flutter, Blood pressure, Bradycardia, Cardiac, Cardiac arrest, Cardiac arrhythmias, Cardiac muscle, Cardiovascular effects, Chloroquine, Chloroquine base, Chloroquine poisoning, Chloroquine toxicity, Cubic centimeters, Diastolic pressure, Dos, Dose graph, Electrical arrest, Electrocardiogram, Electrocardiographic changes, Falciparum malaria, Femoral vein, Gastrointestinal tract, Isoelectric line, Kilogram, Lethal dose, Palpable pulse, Poisoning, Segment depression, Sinus, Sinus rhythm, Special reference, Systolic pressure, Toxic dose, Ventricular, Ventricular bradycardia, Ventricular rhythm, Ventricular tachycardia, Volume number.
Abstract
Abstract: The cardiovascular effects of acute chloroquine intoxication have been described in three patients and in five animal experiments. The drug appears to act as a potent myocardial poison, reducing the output of the heart and causing disturbances of conduction bradycardia, and arrhythmias. As far as we know, the first two human cases ever, which illustrate the electrocardiographic changes induced by acute chloroquine poisoning, are the ones presented (Patients 1 and 3). The sequence of changes in the electrocardiogram in acute poisoning in dogs is described. Adrenaline was found to be an effective antidote, as well as a preventive drug. Appropriate precautions are suggested to prevent the occurrence of accidental death or induced poisoning. These emphasize the administration of the drug on a weight rather than an age basis. The use of small doses similar to quinidine may prevent drug idiosyncrasy but does not seem to be practical. Considering the widespread use of chloroquine and its increasing administration, it is necessary to consider the precautionary measures outlined on an international scale.
Url:
DOI: 10.1016/0002-8703(70)90371-6
Affiliations:
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A. Don" last="Michael">T. A. Don Michael</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Internal Medicine, N.I.O.C. Hospital, Abadan</wicri:regionArea><wicri:noRegion>Abadan</wicri:noRegion></affiliation></author><author><name sortKey="Aiwazzadeh, S" sort="Aiwazzadeh, S" uniqKey="Aiwazzadeh S" first="S." last="Aiwazzadeh">S. Aiwazzadeh</name><affiliation wicri:level="1"><country xml:lang="fr">Iran</country><wicri:regionArea>Department of Internal Medicine, N.I.O.C. Hospital, Abadan</wicri:regionArea><wicri:noRegion>Abadan</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">American Heart Journal</title><title level="j" type="abbrev">YMHJ</title><idno type="ISSN">0002-8703</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1970">1970</date><biblScope unit="volume">79</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="831">831</biblScope><biblScope unit="page" to="842">842</biblScope></imprint><idno type="ISSN">0002-8703</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0002-8703</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute chloroquine</term><term>Acute poisoning</term><term>Adrenaline</term><term>Angina pectoris</term><term>Animal experiments</term><term>Aortic</term><term>Aortic pressure</term><term>Atria1 flutter</term><term>Atrial flutter</term><term>Blood pressure</term><term>Bradycardia</term><term>Cardiac</term><term>Cardiac arrest</term><term>Cardiac arrhythmias</term><term>Cardiac muscle</term><term>Cardiovascular effects</term><term>Chloroquine</term><term>Chloroquine base</term><term>Chloroquine poisoning</term><term>Chloroquine toxicity</term><term>Cubic centimeters</term><term>Diastolic pressure</term><term>Dos</term><term>Dose graph</term><term>Electrical arrest</term><term>Electrocardiogram</term><term>Electrocardiographic changes</term><term>Falciparum malaria</term><term>Femoral vein</term><term>Gastrointestinal tract</term><term>Isoelectric line</term><term>Kilogram</term><term>Lethal dose</term><term>Palpable pulse</term><term>Poisoning</term><term>Segment depression</term><term>Sinus</term><term>Sinus rhythm</term><term>Special reference</term><term>Systolic pressure</term><term>Toxic dose</term><term>Ventricular</term><term>Ventricular bradycardia</term><term>Ventricular rhythm</term><term>Ventricular tachycardia</term><term>Volume number</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The cardiovascular effects of acute chloroquine intoxication have been described in three patients and in five animal experiments. The drug appears to act as a potent myocardial poison, reducing the output of the heart and causing disturbances of conduction bradycardia, and arrhythmias. As far as we know, the first two human cases ever, which illustrate the electrocardiographic changes induced by acute chloroquine poisoning, are the ones presented (Patients 1 and 3). The sequence of changes in the electrocardiogram in acute poisoning in dogs is described. Adrenaline was found to be an effective antidote, as well as a preventive drug. Appropriate precautions are suggested to prevent the occurrence of accidental death or induced poisoning. These emphasize the administration of the drug on a weight rather than an age basis. The use of small doses similar to quinidine may prevent drug idiosyncrasy but does not seem to be practical. Considering the widespread use of chloroquine and its increasing administration, it is necessary to consider the precautionary measures outlined on an international scale.</div></front></TEI><affiliations><list><country><li>Iran</li></country></list><tree><country name="Iran"><noRegion><name sortKey="Michael, T A Don" sort="Michael, T A Don" uniqKey="Michael T" first="T. A. Don" last="Michael">T. A. Don Michael</name></noRegion><name sortKey="Aiwazzadeh, S" sort="Aiwazzadeh, S" uniqKey="Aiwazzadeh S" first="S." last="Aiwazzadeh">S. Aiwazzadeh</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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